Amyotrophic Lateral Sclerosis (ALS) 

ALS  |  European Network to Cure ALS Annual Meeting (ENCALS 2025)

Evaluation of Digital Clinical Biomarkers for Detecting Disease Progression During the 8-Week Pretreatment Run-In Period of VRG50635 ALS Proof-of-Concept Study

D. Cadavid, D. Katabi, I. Hoffman, A. Tarachandani, I. Choi, R. H. Scannevin, A. Swami, J. Haas, M. Schmidt, W. Tracewell, P. Sandler, B. Shook, T. Haley, S. Raines, R. Hristove, P. Krishna, R. Levy, H. Rahul, S. Yue, C. DeBisschop, C. Guo, H. Kothare, M. Neumann, M. Bartlett, V. Ramanarayanan,  D. Suendermann-Oeft, P. Van Damme, P. Tienari, E. Solje, M. Jokela, A. Genge, C. O’Connell, R. van Eijk, L. van den Berg 

ALS  |  European Network to Cure ALS Annual Meeting (ENCALS 2025) & 3rd Digital Biomarker Summit

Computer Vision based Assessment of Limb Motor Function in ALS using Remote Monitoring of Activities of Daily Living

C. Zhang, O. Roesler, M. Neumann, J. Liscombe, M. Bartlett, J. Zhu, J. Berry, F. Aponte, B. Deliz, V. Wojna, M. Q. Carillo, M. Peña, L. Dugom, R. Bowser, A. Easton, V. Ramanarayanan 

ALS  |  European Network to Cure ALS Annual Meeting (ENCALS 2025)

Longitudinal Analysis of Individual Disease Progression in a Clinical Trial-Eligible ALS Cohort - Comparing Digital Speech Biomarkers to ALSFRS-R

M. Neumann, H. Kothare, D. Suendermann-Oeft, V. Ramanarayanan

ALS  |  Target ALS Annual Meeting 2025

Toward Comprehensive Multimodal Dialog Assessment of Speech, Respiratory, Orofacial and Limb Motor Function in ALS Patients

C. Zhang, O. Roesler, M. Neumann, J. Liscombe, M. Bartlett, J. Zhu, J. Berry, F. Aponte, B. Deliz, V. Wojna, M.Q. Carillo, M. Peña, L. Dugom, R. Bowser, A. Easton, V. Ramanarayanan

ALS  |  American Academy of Neurology Annual Meeting (AAN 2025)

Sensitivity of Digital Clinical Biomarker Endpoints to Detect Disease Progression during the 8-week Pretreatment Run-In Period in Proof-of-Concept ALS Study VGCS-50635-002

D. Cadavid, D. Katabi, I. Hoffman, P. Nanavati, A. Tarachandani, I. Choi, R. H. Scannevin, A. Swami, J. Haas, M. Schmidt, W. Tracewell, P. Sandler, B. Shook, S. Raines, R. Hristove, P. Krishna, R. Levy, H. Rahul, S. Yue, H. Kothare, M. Neumann, M. Bartlett, V. Ramanarayanan,  P. Van Damme, P. Tienari, E. Solje, M. Jokela, A. Genge, C. O’Connell, R. van Eijk, L. van den Berg 

ALS  |  The 35th International Symposium on Amyotrophic Lateral Sclerosis and Motor Neuron Disease (MNDA) 2024

Towards Improving Clinical Trial Design and Participant Stratification in ALS With Digital Speech Biomarkers

M. Neumann, H. Kothare, and V. Ramanarayanan

ALS  |  The 35th International Symposium on Amyotrophic Lateral Sclerosis and Motor Neuron Disease (MNDA) 2024

Linguistic Features of Automatically Transcribed Speech from ALS Patients

A. Arbatti, M. Neumann, and V. Ramanarayanan

ALS  |  Northeast ALS Association (NEALS) Meeting 2024

Towards Personalized Prediction of ALS Disease Progression Trajectories Using Digital Speech Biomarkers

H. Kothare, M. Neumann, D. Suendermann-Oeft and V. Ramanarayanan

ALS  |  Northeast ALS Association (NEALS) Meeting 2024

Canonical Timing Alignment of Read Speech in ALS is Correlated with Perceived Speech Impairment and Listener Effort

H. Kothare, J. Liscombe, M. Neumann, E. Leschly, M. Bartlett, D. Suendermann-Oeft and V. Ramanarayanan

ALS  |  INTERSPEECH 2024 & ENCALS 2024

Multimodal Digital Biomarkers for Longitudinal Tracking of Speech Impairment Severity in ALS: An Investigation of Clinically Important Differences 

M. Neumann, H. Kothare, J. Liscombe, E.C.L. Leschly, O. Roesler and V. Ramanarayanan

ALS  |  INTERSPEECH 2024 & ENCALS 2024

How Consistent are Speech-Based Biomarkers in Remote Tracking of ALS Disease Progression Across Languages? A Case Study of English and Dutch.

H. Kothare, M. Neumann, C. Zhang, J. Liscombe, J.W.J. van Unnik, L.C.M .Botman, L.H. van den Berg, R.P.A. van Eijk and V. Ramanarayanan

ALS  |  International Seminar on Speech Production 2024

On The Utility of a Single-Breath Counting Task for the Remote Digital Assessment of Respiratory Function in ALS

M. Neumann, H. Kothare and V. Ramanarayanan

MODALITY R&D / ALS / SCHIZOPHRENIA / DEPRESSION  |  38th Annual AAAI Conference on Artificial Intelligence (Workshop on Machine Learning for Cognitive and Mental Health) 2024

Towards Remote Differential Diagnosis of Mental and Neurological Disorders Using Automatically Extracted Speech and Facial Features

V. Richter, M. Neumann and V. Ramanarayanan

MODALITY R&D / ALS  |  20th Annual Scientific Meeting of the International Society for CNS Clinical Trials and Methodology (ISCTM) 2024

Relationship Between Sample Size and Responsiveness of Speech-Based Digital Biomarkers in ALS

H. Kothare, M. Neumann and V. Ramanarayanan

🏆 This poster was awarded the “Distinguished Poster Award”.

ALS  |  Motor Speech Conference 2024

Analytical Validation of Canonical Timing Alignment and Other Timing-Related Speech Biomarkers in Amyotrophic Lateral Sclerosis Extracted Automatically Using a Remote Patient Monitoring Platform

J. Liscombe, R. Bajjuri, H. Kothare and V. Ramanarayanan 

ALS  |  Motor Speech Conference 2024

Analytical Validation of Facial Metrics in Amyotrophic Lateral Sclerosis (ALS) Extracted Using a Multimodal Remote Patient Monitoring Platform

C. Zhang, O. Roesler, J. Liscombe, R. Bajjuri, H. Kothare, and V. Ramanarayanan 

ALS  |  American Speech-Language-Hearing Association (ASHA) Convention 2023

Assessing the Utility of Vowel Space Characteristics in Remotely Recorded Speech for ALS Progress Monitoring

M. Neumann, H. Kothare, J. Liscombe, V. Ramanarayanan

ALS  |  INTERSPEECH 2023

Combining Multiple Multimodal Speech Features into an Interpretable Index Score for Capturing Disease Progression in Amyotrophic Lateral Sclerosis

M. Neumann, H. Kothare and V. Ramanarayanan

ALS  |  INTERSPEECH 2023

Responsiveness, Sensitivity and Clinical Utility of Timing-Related Speech Biomarkers for Remote Monitoring of ALS Disease Progression

H. Kothare, M. Neumann, J. Liscombe, J. Green, V. Ramanarayanan 

ALS  |  INTERSPEECH 2023

Remote Assessment for ALS using Multimodal Dialog Agents: Data Quality, Feasibility and Task Compliance

V. Richter, M. Neumann, J. Green, B. Richburg, O. Roesler, H. Kothare, V. Ramanarayanan

ALS  | Speech Motor Control Conference (SMC) 2022

On Timing and Pronunciation Metrics for Intelligibility Assessment in Pathological ALS Speech

J. Liscombe, M. Neumann, H. Kothare, O. Roesler, D. Suendermann-Oeft and V. Ramanarayanan

ALS  |  Annual Meeting of the American Academy of Neurology (AAN) 2022

Lessons Learned From A Large-Scale Audio-Visual Remote Data Collection For Amyotrophic Lateral Sclerosis Research

V. Ramanarayanan, M. Neumann, A. Anvar, D. Suendermann-Oeft, O. Roesler, J. Liscombe, H. Kothare, J. D. Berry, E. Fraenkel, R. Norel, A. V. Sherman, J. Kumm, and I. Navar

ALS  |  Motor Speech Conference 2022

On the Robust Automatic Computation of Speaking and Articulation Duration in ALS Patients Versus Healthy Controls

J. Liscombe, A. Ocampo, H. Kothare, O. Roesler, M. Neumann, D. Habberstad, A. Cornish, D. Pautler, D. Suendermann-Oeft and V. Ramanarayanan

ALS  |  The 32nd International Symposium on Amyotrophic Lateral Sclerosis and Motor Neuron Disease 2021

Multimodal Dialog Based Speech and Facial Biomarkers Capture Differential Disease Progression Rates For ALS Remote Patient Monitoring

M. Neumann, O. Roesler, J. Liscombe, H. Kothare, D. Suendermann-Oeft, J. D. Berry, E. Fraenkel, R. Norel, A. Anvar, I. Navar, A. V. Sherman, J. R. Green and V. Ramanarayanan

SYSTEM  |  International Workshop on Spoken Dialog Systems (IWSDS) 2021

Voice Activity Detection in Dialog Agents for Dysarthric Speakers

J. Liscombe, H. Kothare, M. Neumann, A. Ocampo, O. Roesler, D. Habberstad, A. Cornish, D. Pautler, D. Suendermann-Oeft and V. Ramanarayanan

ALS  |  22nd Annual Conference of the International Speech Communication Association (Interspeech) 2021

Investigating the Utility of Multimodal Conversational Technology and Audiovisual Analytic Measures for the Assessment and Monitoring of Amyotrophic Lateral Sclerosis at Scale

M. Neumann, O. Roesler, J. Liscombe, H. Kothare, D. Suendermann-Oeft, D. Pautler, I. Navar, A. Anvar, J. Kumm, R. Norel, E. Fraenkel, A. Sherman, J. Berry, G. Pattee, J. Wang, J. Green, V. Ramanarayanan

ALS  |  73th Annual Meeting of the American Academy of Neurology (AAN) 2021

Towards A Large-Scale Audio-Visual Corpus for Research on Amyotrophic Lateral Sclerosis

A. Anvar, D. Suendermann-Oeft, D. Pautler, V. Ramanarayanan, J. Kumm, J. Berry, R. Norel, E. Fraenkel, and I. Navar